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03/02/11 4:09 PM ET

Wieters' big day at the plate carries Orioles

CLEARWATER, Fla. -- Matt Wieters went 3-for-4 and drove in two runs to lead the Orioles to a 6-5 victory over the Phillies on Wednesday afternoon at Bright House Field.

Phillies right-hander Roy Oswalt made his Grapefruit League debut. He was the last of five Philadelphia starters to appear in a spring game and allowed one run on two hits and one walk over two innings.

Oswalt is on schedule to start the third game of the regular season on April 3 against the Houston Astros at Citizens Bank Park.

The Phillies took a 1-0 lead in the first inning, when Raul Ibanez hit a two-out single to right field and Ryan Howard doubled off the wall in right-center field to score Ibanez. Ibanez and Howard were a combined 2-for-16 in Grapefruit League at-bats before stringing together back-to-back hits against Orioles right-hander Chris Tillman.

Tillman allowed three hits, one run, one walk and struck out one in two innings.

The Orioles tied the game in the second, when second baseman Brendan Harris doubled into the left-field corner to score Jake Fox. The O's took a 2-1 lead in the third when Randy Winn singled and stole second base against Brad Lidge. Matt Wieters then singled to score Winn.

Wieters added his second RBI single of the game in the fifth inning, and Felix Pie contributed an RBI double in the seventh to stretch the Orioles' lead to 4-1.

Up next for the Phillies: The Phils play the Boston Red Sox on Thursday afternoon in Fort Myers, Fla., at 1:05 p.m. ET. Left-hander Cole Hamels will make his second Grapefruit League start. Shane Victorino is the only everyday player from the 2010 lineup making the trip. Other players making the trip include Domonic Brown, Ben Francisco, Ross Gload and John Mayberry Jr.

Up next for the Orioles: Lefty Brian Matusz will make his Grapefruit League debut in the O's second home game of the spring. Matusz will be followed by Rule 5 Draft pick Adrian Rosario, as well as Kevin Gregg and Koji Uehara, who are battling for the closer's spot. Bullpen hopefuls Jeremy Accardo and Clay Rapada will also throw in the 1:05 p.m. ET contest against the Twins.

Todd Zolecki is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.