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09/15/09 1:00 PM ET

O's open '10 on road, host Jays on April 9

Mets, Marlins, Giants among club's Interleague opponents

BALTIMORE -- With one schedule winding down, it's time for the next one to appear. The Orioles will spend a rare Opening Day on the road in 2010, when they will start off their season April 6 in Tampa Bay. Baltimore has spent 16 of the past 18 season openers at home, with 2007 and 1995 standing as the lone exceptions.

The Orioles opened up in Minnesota in '07, and they started their season in Kansas City in '95. Otherwise, since Camden Yards opened, Baltimore has spent every Opening Day at home. The Orioles will kick off their home schedule April 9 against Toronto, and the Rays will begin a three-game set in Baltimore on April 12.

The Yankees and Red Sox will visit Camden Yards for the first time at the end of April. New York will come in for a three-game set starting on April 27, and the Red Sox will meet the Orioles on April 30. Baltimore will travel to face the Red Sox in April and will go to New York for the first time in the first week of May.

Baltimore's Interleague slate will contain a few interesting quirks. The Orioles will welcome the Marlins and Mets for a pair of three-game series, and they'll play a home-and-home set against the Nationals, their natural rivals. Baltimore will also travel to San Francisco in mid-June and will follow that up with a trip to San Diego.

Baltimore will play road series in both New York and Boston during September, and the Orioles will end their regular season with a four-game set at Camden Yards against the Tigers.

Spencer Fordin is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.