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07/01/09 9:42 PM ET

It's up to Guthrie to keep O's sailing along

Baltimore (35-43) at Los Angeles (42-34), 10:05 p.m. ET

BALTIMORE -- For Orioles manager Dave Trembley, Tuesday night was a game to remember. After trailing for much of the game, the Orioles pulled off the biggest comeback in the club's history to defeat the Red Sox, 11-10.

"I never knew I had so many friends," Trembley said, joking before Wednesday's game. "I got a lot of calls and e-mails about the game. I was here until after 2 a.m. [ET]."

It was a game the players were still clamoring about in the clubhouse on Wednesday, and one the Orioles hope will help carry over when they hit the road to travel to take on the Los Angeles Angels.

It was a thrilling comeback for those still in attendance following a rain delay that lasted more than an hour. But beyond the mark in the win column, Trembley said what impressed him most about the rally was the way his players handled themselves following the victory.

"They acted like they've been there before," Trembley said. "You shake hands and you get off the field. There was no fist pumping, no pulling the gun out of the holster. We did it the right way. We did it with our bat, our glove, throwing it, catching it and running the bases."

For the Orioles, starter Jeremy Guthrie will look to keep that spark going as he tries to get his record back to the .500 mark. The right-hander has won his previous two starts, allowing just four earned runs over those two outings.

Guthrie will have his hands full, however, as he'll face an Angels team that is first in the Majors in batting, hitting a collective .278. They are led by Torii Hunter, who leads the team with 17 home runs and 57 RBIs.

This will be the Orioles' first trip to Los Angeles this season. The Angels visited Baltimore for a two-game series in April, with the Halos winning both games.

Pitching matchup
BAL: RHP Jeremy Guthrie (6-7, 5.11 ERA)
The first inning once again gave Guthrie trouble in his previous start on Saturday. Despite picking up his sixth win of the season, Guthrie allowed three earned runs -- two in the first -- and walked three batters in the Orioles' 6-3 win. After the first, Guthrie calmed down, however, lasting five innings and registering two strikeouts.

LAA: RHP John Lackey (2-3, 5.06 ERA)
Lackey was dominant across seven innings against the D-backs on Saturday, yielding an unearned run on five hits and three walks, striking out nine. Holding his stuff to the finish, he recorded punchouts on six of his final seven outs. Lackey is 6-3 with a 3.46 ERA in 10 career meetings against the Orioles.

The Orioles are now 29-2 this season when leading after eight innings. Their previous loss came on April 24 in a game vs. the Rangers. ... Brian Roberts' stolen base in the first inning on Wednesday was the first swipe for Baltimore since June 21 in Philadelphia. ... Brad Bergesen has made six quality starts at home and has received five or more runs of support in 10 of his 14 starts. ... Over his past five games, Felix Pie is hitting .438 and is riding a five-game hitting streak over that span.

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On the Internet
 Gameday Audio
•  Gameday
•  Official game notes

On television

On radio
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Up next
• Friday: Orioles (David Hernandez, 1-2, 4.19) at Angels (Ervin Santana, 1-3, 7.47), 10:05 p.m. ET
• Saturday: Orioles (Jason Berken, 1-5, 6.44) at Angels (Matt Palmer, 7-1, 5.16), 9:05 p.m. ET
• Sunday: Orioles (Rich Hill, 3-2, 7.08) at Angels (Joe Saunders, 8-5, 4.24), 3:35 p.m. ET

Brian Eller is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.