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05/20/09 1:43 AM ET

Back to business as usual for O's, Guthrie

Baltimore (16-23) at New York (22-17), 7:05 p.m. ET

NEW YORK -- First impressions are over. Now it's time for the Orioles to leave their mark.

Baltimore played its first game in the new Yankee Stadium on Tuesday night and lost by a one-sided margin, a 9-1 score that conceals how close things were for most of the night.

Perhaps more importantly, the Orioles got their first taste of a new stadium and will go back to business as usual on Wednesday.

Manager Dave Trembley took a moment to note his first impressions of the stadium Tuesday night, comparing it and contrasting it to the famed House That Ruth Built situated right across the street.

"I think the older stadium is louder," he said. "It seemed like in the older stadium, the fans are more on top of the field. Here, it's more of a distance thing. The backstop and home plate is closer, but everything else seems to be at much more of a distance ... The other stadium, it seemed like everybody's right on top of you."

Trembley saw the Yankees come down on top of his team Tuesday night with a seven-run rally that put the game away, but he knows that the Orioles have their staff ace on the hill Wednesday. Jeremy Guthrie will get the ball for Baltimore, and he'll be matched against struggling youngster Phil Hughes.

That's as favorable a matchup as the Orioles will get against New York, and Guthrie will be going for his second straight win. Baltimore hasn't won a series on the road since the first week of the season, and the Orioles have posted a 7-14 record thus far against American League East division rivals.

They're also 5-12 on the road, a mark that stands with Minnesota and Oakland among the worst in the league. The Orioles won their first two games against the Yankees this season but have dropped four of the past five in this series. If you take that trend further, Baltimore has lost 10 of its past 13 games in New York.

Pitching matchup
BAL: RHP Jeremy Guthrie (3-3, 5.21 ERA)
Guthrie labored through five innings but picked up a win over Kansas City in his last start. Guthrie equaled a season-low with just two strikeouts and wound up allowing six hits and four earned runs.

NYY: RHP Phil Hughes (1-2, 7.56 ERA)
The last time Hughes faced the Orioles, he allowed eight earned runs and was knocked out in the second inning. Now he'll have a chance for revenge in what could be a make-or-break start for Hughes' future in the rotation.

Bird bites
The Orioles set a season low with three hits in their series opener against the Yankees. ...Baltimore hasn't homered in 31 innings, a span that reaches all the way back to the fourth inning of last Thursday's game against Kansas City. ...The Orioles are the only team in the Majors without a successful pinch-hit this season. ...Baltimore has been outscored 40-4 in the seventh inning this season. The Orioles are 0-20 when trailing after seven innings and 13-1 when leading after seven. ...Baltimore is 11-11 when it scores first and 5-12 when its opponent draws first blood.

 Buy tickets now to catch the game in person.

On the Internet
 Gameday Audio
•  Gameday
•  Official game notes

On television

On radio
• 105.7 The Fan

Up next
• Thursday: Orioles (Adam Eaton, 2-4, 7.93) at Yankees (Joba Chamberlain, 2-1, 3.76), 7:05 p.m. ET
• Friday: Orioles (Rich Hill, 1-0, 3.18) at Nationals (Jordan Zimmermann, 2-1, 6.35), 7:05 p.m. ET
• Saturday: Orioles (Koji Uehara, 2-3, 4.34) at Nationals (TBD), 7:05 p.m. ET

Spencer Fordin is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.