HOUSTON -- Cubs-White Sox, Yankees-Mets, Cardinals-Royals and … Astros-Rockies? With the Astros making the switch to the American League this season, Colorado and Houston has become a new annual Interleague rivalry, and an odd one at that.

Rockies veteran Todd Helton said the lack of history between the two teams is obvious, but he likes coming to Houston.

"Great ballpark, plenty of hunting magazines and hot weather," he quipped about the city. "I'm on board."

Third baseman Nolan Arenado said the two squads are more similar than ever, despite now being in separate leagues.

"It's going to be a good series," Arenado said. "They have a great venue and have a young team full of highly-regarded guys, a lot like us. They want to get back up to the top, and so do we. We're a little closer right now, but it's two teams that have something to prove in the next few years."

Colorado manager Walt Weiss said he's still adjusting to the Astros' new affiliation.

"It's just weird to me," he said. "It's hard for me to fathom that the Astros are in the American League. It was late last night before I realized I'd need a DH today. I just don't think of them as an AL club."

The two teams met 159 times as National League members, with Houston owning a slight 80-79 advantage.

The Astros' move to the AL also created continous Interleague Play, which Weiss was less than enthusiastic about.

"I'm kind of lukewarm on Interleague Play, to be honest," Weiss said. "I like the fact that the leagues used to be separate. I know it creates some pretty cool matchups, but I'm still a big fan of the separate leagues.

Sore wrist limits Cuddyer to bench role in opener

COL@SF: Cuddyer opens the scoring with two-run double

HOUSTON -- Michael Cuddyer started on the bench Monday due to swelling in his right wrist area, but the outfielder was summoned in the late innings of the Rockies' 3-2 loss to the Astros.

Cuddyer went 0-for-1 with an intentional walk in the 12-inning affair, playing right field after initially pinch-hitting in the 10th. He was out of the starting lineup after being hit by a pitch during Sunday's game against San Francisco.

X-rays on the wrist showed no break, but manager Walt Weiss said he was trying to avoid playing Cuddyer in Houston.

"You try to stay away from playing him or needing to, but if they got spikes on, they're available," Weiss said.

Cuddyer struck out to end the top of the 12th, and the Astros' game-winning ground-rule double fell just beyond his glove's reach near the right-field line.

"I was wanting to stay away from Cuddy, but he was swinging during the game and convinced me that he was OK," Weiss said. "For me, he was going to be a last resort. … He's doing well, but it's still swollen. It's always tough when you have an injury down around your hand or your wrist. That makes it difficult to swing the bat."

Cuddyer's right forearm was heavily wrapped during warmups, but neither he nor Weiss was sure if any further protective braces or wraps would be necessary.

The 34-year-old returned from the disabled list on May 24 and promptly put up three doubles and a home run in three games against the Giants before San Francisco reliever George Kontos hit him with a pitch in the sixth inning.

Cuddyer said he couldn't grip a bat or throw after Sunday's game, but Weiss said the pain had somewhat subsided overnight, as Cuddyer was throwing the ball gingerly in the outfield 90 minutes before the game.